IOX1 / 5 MG
Properties
| Flash Point (C) | Not available |
| Flash Point (F) | Not available |
Product Description
IOX1 is a small molecule inhibitor known for its ability to inhibit the activity of histone demethylases, specifically those targeting the Jumonji C domain-containing proteins. It is utilized in research settings to study epigenetic regulation and its implications in various biological processes.
Application:
IOX1 is commonly used as a research tool to investigate the role of histone demethylases in epigenetic regulation. It is applied in studies aiming to understand the molecular mechanisms underlying gene expression, cell differentiation, and disease progression.
Articles:
- Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2
Publication Date: November 03, 2022
Xiao Hu, Yanli Zou, David A. Copland, Lauren P. Schewitz-Bowers, Yan Li, Philippa J.P. Lait, Madeleine Stimpson, Zhihui Zhang, Shixin Guo, Juanran Liang, Tingting Chen, Jing Jing Li, Sujing Yuan, Shuo Li, Penghui Zhou, Yizhi Liu, Andrew D. Dick, Xiaofeng Wen, Richard W.J. Lee, Lai Wei
https://doi.org/10.1016/j.ebiom.2022.104333
- Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy
Publication Date: 23 April 2021
Jing Liu, Zhihao Zhao, Nasha Qiu, Quan Zhou, Guowei Wang, Haiping Jiang, Ying Piao, Zhuxian Zhou, Jianbin Tang & Youqing Shen
https://doi.org/10.1038/s41467-021-22407-6
- IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis through Inhibition of KDM3 Histone Demethylases
Publication Date: JANUARY 05 2021
Rosalie G. Hoyle; Huiqun Wang; Yana Cen; Yan Zhang; Jiong Li