(R)-PFI-2

(R)-PFI-2 is a potent and selective inhibitor of the histone methyltransferase SETD7. It is used in research settings to study the role of SETD7 in epigenetic regulation and its potential as a therapeutic target in cancer and other diseases.

Application:

(R)-PFI-2 is primarily used as a research tool to study the function of SETD7 and its implications in various cellular processes, including gene expression, cell proliferation, and differentiation. It is also investigated for its potential therapeutic applications in cancer and other diseases associated with dysregulated histone methylation.

Articles:

- Revealing inhibition difference between PFI-2 enantiomers against SETD7 by molecular dynamics simulations, binding free energy calculations and unbinding pathway analysis

Publication Date: 18 April 2017

Yuzhen Niu, Danfeng Shi, Lanlan Li, Jingyun Guo, Huanxiang Liu & Xiaojun Yao

https://doi.org/10.1038/srep46547

- Activating transcriptional coactivator with PDZ-binding motif by (R)-PFI-2 attenuates osteoclastogenesis and prevents ovariectomized-induced osteoporosis

Publication Date: Available online 2 December 2023

Rongjian Xu, Xuewen Liu, Yufeng Zhang, Kelei Wang, Zhuolin Chen, Jiewen Zheng, Tan Zhang, Peijian Tong, Yu Qian, Wanlei Yang

https://doi.org/10.1016/j.bcp.2023.115964

- The Anti-Inflammatory Effects of Small Molecule Mediator (R)- PFI-2 in the Temporomandibular Joints of Rat and Mice Exposed to Common Inflammatory Mediators

Publication Date: 2019-03-06

Briggs, Stephanie Renee

https://hdl.handle.net/1969.1/184926